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LeafSource Research Home Page

Department of Pharmaceutical Sciences



For seven years the research team at Mercer University School of Pharmacy has conducted controlled scientific experiments on the product known as LeafSource™. Our team at Mercer University, which consists of three Ph.D. scientists and two graduate students have collectively greater than 100 years of scientific research experience, more than 300 scientific publications, over 20 patents (both US and International), and many scientific presentations. The past seven years has afforded us an opportunity to evaluate LeafSource™ products (in liquid and in dry form) as they relate to their potential as pharmaceuticals.

Controlled scientific studies employed the use of Sprague-Dawley rats in order to study the effects that LeafSource™ would have on mammalian systems. These studies were performed using sound scientific methodologies and methods included the use of test animals, which were randomly placed into various groups. Typically, these groups included the test groups receiving LeafSource™, a positive control group that didn’t receive anything, and a second control group that received a commercial/experimental product possessing the desired effect. The various groups provide reliable, reproducible results which are standard methods for peer-accepted research.

In one of our studies, we observed that LeafSource™ was capable of inhibiting both acute inflammation induced by carrageenan as well as adjuvant arthritis induced by Mycobacterium butyricum when used at sub-therapeutic levels (2 mg/kg po) of indomethacin, a known anti-inflammatory agent. In these studies, we showed that LeafSourceincreased the anti-inflammatory effects of indomethacin at 2 and 3 hours by 64% and 104%, respectively. We also observed that in the adjuvant models, LeafSource™ produced a reduction in the inflammation 15 days after the initiation of the disease. This is of particular interest because the disease is regulated by the immune system. Based on this observation, we determined if there was an effect on the immune system by LeafSource™. This led us to develop an assay for evaluating the effects of LeafSource™ on the cellular and humoral immune response of lymphocytes.

The immune system is divided into two major divisions: the cellular and the humoral immune system. While the cellular immune system has a variety of functions including preventing infections of the body, rejecting foreign tissue, and scanning the body for abnormal tissue growth (cancer), the humoral immune system is primarily responsible for protecting the body against high-grade pathogens prior to their entering cells. The major effector cell of the cellular immune system is the T-lymphocyte while in the humoral immune system, B-lymphocytes attack the foreign substance and, along with help from T-lymphocytes, form antibodies which will attack the foreign organisms.

The common link between these two systems is the T-lymphocyte. Through the use of a mitogen, such as concanavalin A (Con A), we can evaluate the responsiveness of

T-lymphocytes, which is turn provides us with an idea of the function of the cellular immune system. Patients suffering from AIDs or Cancer will have depressed cellular immune systems. So, a product capable of raising the cellular immune system may benefit these patients. Our experiments were designed to evaluate the role LeafSource™ might play on influencing the total number of lymphocytes produced and the responsiveness of the lymphocytes to mitogens.

In the lymphocytes experiments, results showed that LeafSourcecaused an increase in lymphocytes numbers of 17% and 43% after 30 and 60 days, respectively. Further, the lymphocyte responsiveness increased by 14% during this period of time. This data suggests that LeafSource is capable of not only stimulating the production of lymphocytes, but also their responsiveness to foreign substances. Increased lymphocytes numbers could result in better cellular and humoral immune responsiveness, which could reflect in better immunity against antigens and result in lower rates of infections. Further, increases in lymphocytes responsiveness suggests a greater ability of the immune system to respond to foreign substances, including viruses. These results suggest chronic dosing with LeafSource™ may have an effect on the immune system which could be beneficial in a number of different disease states, including improving the immune system in patients suffering from AIDs.

Further, the effects of LeafSourceon the total number of White Blood Cells showed an increase of 21% and 30% after 30 and 60 days, respectively. Of particular interest is the increase of Neutrophils by 57% and 123% after 30 and 60 days, respectively. As you may be aware, these forms of White Blood Cells are required to fight infections of the body. Based on our studies it appears that LeafSource may have a positive effect on the overall immune system. The significance of these findings is these products may have potential usefulness in those diseases of the human body which would benefit from an improved immune system.

We very much look forward to continuing our work with LeafSource™ to gain further insight into the uses it possesses in the field of medicine.

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